# Cryo-EM reveals conserved baseplate-architecture and distinct accessory-protein assemblies in mycobacteriophages Claus, Corndog and Mysterious

Source: [nature.com](https://www.nature.com/articles/s41467-026-79213-1) · 2026-11-10 · Life
Page: https://themorning.science/story/cryo-em-reveals-conserved-baseplate-architecture-and-distinct-accessory-protein-bb2a3fe1e804e3e2
Kind: research · Impact: medium

## In brief

- Cryo-EM structures at atomic resolution were reported for three mycobacteriophages: Claus, Corndog and Mysterious.
- The three phages share a conserved baseplate core.
- Each phage decorates that core with different accessory proteins, which helps explain how related siphophages build distinct baseplates.

## Why it matters

The work shows how closely related mycobacteriophages can share a conserved baseplate core while differing in accessory proteins, which is useful background for researchers studying phage structure and host infection.

## Timeline

- 2026-11-10: Published online in Nature Communications (doi:10.1038/s41467-026-79213-1)

## Coverage

- [Cryo-EM reveals conserved baseplate-architecture and distinct accessory-protein assemblies in mycobacteriophages Claus, Corndog and Mysterious](https://www.nature.com/articles/s41467-026-79213-1) — nature.com, 2026-11-10

Tags: cryo-em, bacteriophage, mycobacteriophage, baseplate, structural biology

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science