# Circulating HSPCs enhance their self-renewal by augmenting the endocytosis and lysosomal acidity via MIF-(CXCR4_CD74)-ATP6V1A axis

Source: [Biological sciences : nature.com subject feeds](https://www.nature.com/articles/s42003-026-11120-z) · 2026-11-14 · Life
Page: https://themorning.science/story/circulating-hspcs-enhance-their-self-renewal-by-augmenting-the-endocytosis-and-l-482d56352ab66c2f
Kind: research · Impact: low

## In brief

- A study reports that circulating hematopoietic stem and progenitor cells (HSPCs) enhance their self-renewal.
- The reported mechanism involves increased endocytosis and lysosomal acidity.
- The headline names a MIF-(CXCR4_CD74)-ATP6V1A axis as the pathway involved.

## Why it matters

It offers a proposed molecular mechanism by which circulating blood stem cells maintain self-renewal, which is relevant to stem cell and hematopoiesis research.

## Timeline

- 2026-11-14: Study listed in nature.com biological sciences subject feed

## Coverage

- [Circulating HSPCs enhance their self-renewal by augmenting the endocytosis and lysosomal acidity via MIF-(CXCR4_CD74)-ATP6V1A axis](https://www.nature.com/articles/s42003-026-11120-z) — Biological sciences : nature.com subject feeds, 2026-11-14

Tags: stem cells, hematopoiesis, self-renewal, lysosome, endocytosis

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science