# Cas12a-based combinatorial knockout screens define the genetic architecture of the DNA damage response

Source: [nature.com](https://www.nature.com/articles/s41587-026-03339-2) · 2026-11-06 · Life
Page: https://themorning.science/story/cas12a-based-combinatorial-knockout-screens-define-the-genetic-architecture-of-t-b94e0a2894356ecc

Nature Biotechnology, Published online: 06 November 2026; doi:10.1038/s41587-026-03339-2 A genetic interaction map of the DNA damage response (DDR) identifies functional relationships among DDR genes and pathways.

## Coverage

- [Cas12a-based combinatorial knockout screens define the genetic architecture of the DNA damage response](https://www.nature.com/articles/s41587-026-03339-2) — nature.com, 2026-11-06

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