# Calpain-mediated TBP cleavage disturbs neuronal AMOT-YAP1 signalling

Source: [nature.com](https://www.nature.com/articles/s41467-026-79055-x) · 2026-11-09 · Life
Page: https://themorning.science/story/calpain-mediated-tbp-cleavage-disturbs-neuronal-amot-yap1-signalling-0d62cad9c7e54600
Kind: research · Impact: low

## In brief

- The study reports that TBP fragments activate calpains in neurons.
- The activated calpains disrupt AMOT-YAP1 signalling.
- The pathway is involved in normal neural development and is implicated in spinocerebellar ataxia type 17.

## Why it matters

The findings link TBP cleavage by calpains to disruption of AMOT-YAP1 signalling, a possible mechanism in spinocerebellar ataxia type 17 that science readers working on neurodegeneration or neural development may want to follow.

## Timeline

- 2026-11-09: Study published online in Nature Communications

## Coverage

- [Calpain-mediated TBP cleavage disturbs neuronal AMOT-YAP1 signalling](https://www.nature.com/articles/s41467-026-79055-x) — nature.com, 2026-11-09

Tags: neuroscience, calpain, yap1, spinocerebellar ataxia 17, neural development

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science