# Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc

Source: [cell.com](https://www.cell.com/current-biology/fulltext/S0960-9822(26)01417-X?rss=yes) · 2026-11-09 · Life
Page: https://themorning.science/story/apical-extracellular-matrix-regulates-fold-morphogenesis-in-the-drosophila-wing-57629b296b5784b8
Kind: research · Impact: low

## In brief

- Fuhrmann, Schimmenti and colleagues quantified fold morphology on 3D apical surfaces of the Drosophila wing disc epithelium.
- Using ultrastructure analysis, physical modeling and genetic perturbation, they report that folds adhere apically to the apical extracellular matrix.
- The study links this apical adhesion to how folds form during wing disc morphogenesis.

## Why it matters

The work shows that the apical extracellular matrix can shape epithelial folding in a developing tissue, which matters for researchers studying how tissues acquire their three-dimensional form.

## Timeline

- 2026-11-09: Article published by cell.com

## Coverage

- [Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc](https://www.cell.com/current-biology/fulltext/S0960-9822(26)01417-X?rss=yes) — cell.com, 2026-11-09

Tags: drosophila, wing disc, morphogenesis, extracellular matrix, epithelium

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science