# Anticoagulants Reign Supreme in VTE Prevention After Joint Replacement

Source: [MedPageToday.com - medical news for physicians](https://www.medpagetoday.com/cardiology/venousthrombosis/123840) · 2026-11-11 · Medicine
Page: https://themorning.science/story/anticoagulants-reign-supreme-in-vte-prevention-after-joint-replacement-48bd45719ccb747b
Kind: research · Impact: medium

## In brief

- In the randomized PEPPER trial, aspirin did not prevent venous thromboembolism (VTE) as well as anticoagulants did in patients undergoing elective hip or knee replacement.
- The trial's primary composite endpoint included death from VTE-related causes; the full endpoint definition is not given in the available source excerpt.

## Why it matters

The results bear on which thromboprophylaxis drug is chosen after elective hip or knee replacement, a common procedure where VTE is a recognised risk.

## Coverage

- [Anticoagulants Reign Supreme in VTE Prevention After Joint Replacement](https://www.medpagetoday.com/cardiology/venousthrombosis/123840) — MedPageToday.com - medical news for physicians, 2026-11-11

Tags: venous thromboembolism, joint replacement, anticoagulants, aspirin, clinical trial

---

Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science