# Antagonistic second-messenger signalling coordinates Pseudomonas aeruginosa surface colonization and virulence

Source: [nature.com](https://www.nature.com/articles/s41467-026-79432-6) · 2026-11-07 · Life
Page: https://themorning.science/story/antagonistic-second-messenger-signalling-coordinates-pseudomonas-aeruginosa-surf-723e4950a4dd9476
Kind: research · Impact: low

## In brief

- Study published in Nature Communications on 7 November 2026 examines Pseudomonas aeruginosa surface colonization and virulence.
- The second messengers cAMP and c-di-GMP regulate surface behaviours and virulence in this bacterium.
- The authors report how the bacteria switch between attachment and surface-associated states, with the two signalling systems acting antagonistically.

## Why it matters

Pseudomonas aeruginosa is a significant opportunistic pathogen, so clarifying how its signalling controls surface attachment and virulence may inform future research into bacterial infection.

## Timeline

- 2026-11-07: Published online in Nature Communications

## Coverage

- [Antagonistic second-messenger signalling coordinates Pseudomonas aeruginosa surface colonization and virulence](https://www.nature.com/articles/s41467-026-79432-6) — nature.com, 2026-11-07

Tags: pseudomonas aeruginosa, second messengers, c-di-gmp, camp, virulence, bacterial signalling

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science