# An ulcerative colitis taxonomy defined by individual patient-reported response trajectories

Source: [nature.com](https://www.nature.com/articles/s41591-026-04741-8) · 2026-11-09 · Medicine
Page: https://themorning.science/story/an-ulcerative-colitis-taxonomy-defined-by-individual-patient-reported-response-t-40639fc23f843f31
Kind: research · Impact: medium

## In brief

- An analysis of patient-reported response trajectories to vedolizumab in ulcerative colitis defines disease endotypes.
- The study identifies vascular inflammation as a potential resistance mechanism to vedolizumab.
- The work was published online in Nature Medicine on 9 November 2026 (doi:10.1038/s41591-026-04741-8).

## Why it matters

Grouping ulcerative colitis patients by their individual response trajectories could help explain why some patients do not respond to vedolizumab and point to possible targets for treatment resistance.

## Timeline

- 2026-11-09: Study published online in Nature Medicine

## Coverage

- [An ulcerative colitis taxonomy defined by individual patient-reported response trajectories](https://www.nature.com/articles/s41591-026-04741-8) — nature.com, 2026-11-09

Tags: ulcerative colitis, vedolizumab, inflammatory bowel disease, patient-reported outcomes, endotypes, vascular inflammation

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science