# An LHX2-DACH1 regulatory innovation drives basal progenitor expansion in the primate neocortex

Source: [science.org](https://www.science.org/doi/abs/10.1126/sciadv.aed3856?af=R) · 2026-11-13 · Life
Page: https://themorning.science/story/an-lhx2-dach1-regulatory-innovation-drives-basal-progenitor-expansion-in-the-pri-ae4dbe49c847e36c
Kind: research · Impact: medium

## In brief

- A study in Science Advances reports an LHX2-DACH1 regulatory innovation linked to basal progenitor expansion in the primate neocortex.
- The paper appeared in Science Advances Volume 12, Issue 46, in November 2026.
- The available source is the journal listing; its full methods and results were not provided.

## Why it matters

The work points to a specific gene-regulatory change that may help explain how the primate neocortex gained its expanded progenitor population, a key question in brain evolution and development.

## Timeline

- 2026-11-13: Published in Science Advances (Volume 12, Issue 46)

## Coverage

- [An LHX2-DACH1 regulatory innovation drives basal progenitor expansion in the primate neocortex](https://www.science.org/doi/abs/10.1126/sciadv.aed3856?af=R) — science.org, 2026-11-13

Tags: neocortex, neurodevelopment, basal progenitors, gene regulation, primate evolution

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science