# Adipogenic MSC-derived COL-3 drives M2-like macrophage polarization via PI3K-AKT to alleviate sepsis-induced lung injury

Source: [Biological sciences : nature.com subject feeds](https://www.nature.com/articles/s41598-026-79337-w) · 2026-11-10 · Life
Page: https://themorning.science/story/adipogenic-msc-derived-col-3-drives-m2-like-macrophage-polarization-via-pi3k-akt-6ed41a7c108fb181
Kind: research · Impact: low

## In brief

- A study reports that COL-3 derived from adipogenic mesenchymal stem cells drives M2-like macrophage polarization.
- The reported mechanism involves the PI3K-AKT pathway.
- The study reports that this process alleviates sepsis-induced lung injury.

## Why it matters

It identifies a candidate mechanism, macrophage polarization via PI3K-AKT, by which stem-cell-derived COL-3 may limit lung damage in sepsis, which can guide future mechanistic and therapeutic research.

## Coverage

- [Adipogenic MSC-derived COL-3 drives M2-like macrophage polarization via PI3K-AKT to alleviate sepsis-induced lung injury](https://www.nature.com/articles/s41598-026-79337-w) — Biological sciences : nature.com subject feeds, 2026-11-10

Tags: sepsis, macrophages, mesenchymal stem cells, lung injury, pi3k-akt

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science