# A lysosomal DRAM1-GLUT1-NADPH axis coordinates glucose sensing with metabolic reprogramming

Source: [cell.com](https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00742-2?rss=yes) · 2026-11-12 · Life
Page: https://themorning.science/story/a-lysosomal-dram1-glut1-nadph-axis-coordinates-glucose-sensing-with-metabolic-re-428d6cce0f11e814
Kind: research · Impact: low

## In brief

- Li et al. report a lysosome-based feedback system that helps cells adapt to excess glucose.
- High glucose increases DRAM1 and NADPH, which promotes retention of the glucose transporter GLUT1 at lysosomes.
- With GLUT1 held at lysosomes, glucose entry and glycolysis fall, and cells shift toward greater reliance on glutamine.

## Why it matters

The work describes a mechanism linking glucose sensing at lysosomes to metabolic reprogramming, which could inform research on how cells regulate glucose uptake and fuel use.

## Timeline

- 2026-11-12: Study published in Molecular Cell

## Coverage

- [A lysosomal DRAM1-GLUT1-NADPH axis coordinates glucose sensing with metabolic reprogramming](https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00742-2?rss=yes) — cell.com, 2026-11-12

Tags: metabolism, lysosome, glucose, glut1, glutamine, glycolysis

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science