# A lactate-fatty acid loop drives prostate cancer bone colonization by mediating metabolic interplay between tumor cells and osteoblasts

Source: [nature.com](https://www.nature.com/articles/s41467-026-79651-x) · 2026-11-10 · Life
Page: https://themorning.science/story/a-lactate-fatty-acid-loop-drives-prostate-cancer-bone-colonization-by-mediating-28189e4e2b3cbcfc
Kind: research · Impact: medium

## In brief

- Bone metastases in advanced prostate cancer are difficult to treat and are associated with poor outcomes.
- The authors report that bone-colonizing prostate tumor cells exploit lactate, according to the article's abstract, which is truncated in the source.
- The study is published in Nature Communications with doi 10.1038/s41467-026-79651-x.

## Why it matters

It points to metabolic interplay between prostate tumor cells and bone-forming osteoblasts as a possible target for treating bone metastases, which currently have poor outcomes.

## Timeline

- 2026-11-10: Published online in Nature Communications

## Coverage

- [A lactate-fatty acid loop drives prostate cancer bone colonization by mediating metabolic interplay between tumor cells and osteoblasts](https://www.nature.com/articles/s41467-026-79651-x) — nature.com, 2026-11-10

Tags: prostate cancer, bone metastasis, lactate, tumor metabolism, osteoblasts

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Brief generated by AI (claude-haiku-5-5) from the reporting listed under Coverage. Headlines belong to their publishers. The Morning Science – https://themorning.science